Fisetin-isonicotinamide co-crystal and a method for preparing fisetin-isonicotinamide co-crystal

摘要

the invention relates to kokrysztalu fizetyna - izonikotynamid model 3, which applies in a pharmaceutical and / or cosmetics.the invention discloses also a way receive kokrysztalu fizetyna - izonikotynamid model 3, charakteryzujacy thatwith fizetyne in amounts of from 25 to 50 mg and izonikotynamid in of 150 to 300 mg dissolved in 5 to 10 ml of ethanol or methanol, after which together stirs, przesacza,and then leaves for slow evaporation at room temperature, and after 7 to 21 days they harvest krysztaly.in another variation of receiving kokrysztalu fizetyna - izonikotynamid model 3 in a steel vessel mlyna ball placed to fizetyne and izonikotynamid in of a stoichiometric 1:1.then the following are polar, aprotyczny solvent in amounts of 50? l for every 50 mg fizetyny, then together have the time from 5 to 45 minutes.and so obtained microcrystalline material drought in room temperature for a period of from 12 to 24 hours and subjected to analysis dyfraktometrze proszkowym.