New therapeutic strategies to treat neuroinflammatory conditions

摘要

A composition comprising a combination of at least two compounds selected from an endothelial permeability modulator and an extracellular matrix formation modulator, wherein the endothelial permeability modulator is selected from irbesartan, bosentan, fondaparinux, Pentazocine, nifuroxazide, tiludronate, gliclazide and loperamide, and the modulator of the formation of the extracellular matrix is selected from idraparinux, otamixabán, argatroban, lisinopril, quinapril, ramipril, enoxaparin, disulfiram and spironolactone or salts or derivatives or prodrugs or derivatives Sustained release of these, for use in the treatment of neuroinflammation.