Andrographolide as a potential anti-neuroinflammatory therapeutic:mechanisms of action and clinical utility

摘要

Dysregulation of neuroinflammatory responses has been implicated in a number of disease conditions,including neurodegeneration,stroke,and encephalitis,but to date there is no non-steroidal anti-neuroinflammatory which has been shown to be of sufficient efficacy for clinical use. In my talk, I will overview the research performed by us and others on the potential use of andrographolide,a bioactive labdane diterpenoid derived from the herb Andrographis panuculata as a neuro-inflammatory.Furthre-more,I will also review the current knowledge about andrographolide′s putative molecular mechanisms of action,research gaps,as well as future work which are aimed at increasing the compound′s efficacy and potential clinical utility.