Cyclohexylpyrazol-lactam derivatives as 11-beta-hydroxysteroid dehydrogenase 1 inhibitors

摘要

A compound structurally represented by the formula: ** Formula ** in which: R1 is -H, 5-halogen, -O-CH3 (optionally substituted with one to three halogens) or -CH3 (optionally substituted with one to three halogens ); R2 is -H, -halogen, -O-CH3 (optionally substituted with one to three halogens) or -CH3 (optionally substituted with one to three halogens); R3 is -H or -halogen; R4 is -OH, -halogen, -cyano, -alkyl (C1-C4) (optionally substituted with one to three halogens), -alkoxy (C1-C6) (optionally substituted with one to three halogens), -SCF3, -C (O) O-C1-C4 alkyl, -O-CH2-C (O) NH2, -cycloalkyl (C3-C8), -O-phenyl-C (O) O-alkyl (C1-C4), - CH2-phenyl, -NHSO2-alkyl (C1-C4), -NHSO2-phenyl (R21) (R21), -alkyl (C1-C4) -C (O) N (R10) (R11), -C (O) N (R10) (R11), ** Formula ** in which the dashed line represents the point of attachment to the R4 position of formula I; in which m is 1, 2 or 3; where n is 0, 1 or 2; and in which when n is 0, then "(CH2) n" is a link; R5 is -H, -halogen, -OH, -CN, -C1-C4 alkyl (optionally substituted with 1 to 3 halogens), -C (O) OH, -C (O) O-C1-C4 alkyl ), -C (O) -C1-C4 alkyl, 5-O-C1-C4 alkyl (optionally substituted with 1 to 3 halogens), -SO2-C1-C4 alkyl, -N (R8) (R8), -phenyl (R21) (R21), -C (O) -NH-cycloalkyl (C3-C6), ** Formula ** in which the dashed line represents the point of attachment to the position indicated by R5 ; in which m is 1, 2 or 3; in which n is 0, 1 or 2, and in which when n is 0, then "(CH2) n" is a link; R6 is -H, -halogen, -CN or-(C1-C4) alkyl (optionally substituted with 1 to 3 halogens), -O-(C1-C4) alkyl (optionally substituted with 1 to 3 halogens) or ** Formula ** R7 is -H, -halogen or-(C1-C4) alkyl (optionally substituted with 1 to 3 halogens); R8 is, independently at each occurrence, -H, -C1-C6 alkyl (optionally substituted with 1 to 3 halogens), -C (O) -C1-C6 alkyl (optionally substituted with 1 to 3 halogens ), -C (O) -C3-C8-cycloalkyl, - S (O2) -C3-C8 -cycloalkyl or -S (O2) -C1-C3-alkyl (optionally substituted with 1 to 3 halogens); R9 is -H or -halogen; R10 and R11 are each, independently, -H or -C1-C4 alkyl, or R10 and R11 taken together with the nitrogen to which they are attached form piperidinyl, piperazinyl or pyrrolidinyl; R20 is, independently at each occurrence, -H or -C1-C3 alkyl (optionally substituted with 1 to 3 halogens); R21 is, independently at each occurrence, -H, -halogen or-(C1-C3) alkyl (optionally substituted with 1 to 3 halogens); R22 is, independently at each occurrence, -H or -C1-C6 alkyl (optionally substituted with 1 to 3 halogens); and R23 is, independently at each occurrence, -H, -C1-C4 alkyl or -C (O) O-C1-C4 alkyl; or a pharmaceutically acceptable salt thereof.