Quinazoline compounds as sodium channel blockers

摘要

Compound having Formula I: ** Formula ** or a pharmaceutically acceptable salt or solvate thereof, wherein: R1, R2, R3 and R4 are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl , halogen, hydroxy, hydroxyalkyl, haloalkyl, cyano; amino, alkylamino, dialkylamino, alkoxy, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkylcarbonylamino, alkylcarbonyloxy, carboxy, alkoxycarbonyl, aminosulfonyl, alkylsulfonylamino, (alkylsulfonylamino) alkyl, ureido, (aminocarbonyl) alkylamino and (carboxyalkyl) amino; G is G1, G2, G3 or G4, where G1 is -NR5R6, where R5 is H, alkyl or NH2, R6 is a) H, b) alkyl, c) hydroxyalkyl, d) (aminocarbonyl) alkyl, e) (aminocarbonyl) (hydroxy) alkyl; f) aminoalkyl, g) alkylaminoalkyl, h) dialkylaminoalkyl, i) cycloalkyl, unsubstituted or substituted with one or more substituents, each independently selected from the group consisting of alkyl, alkoxy, halogen, haloalkyl, haloalkoxy, hydroxy, hydroxyalkyl, amino, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, aminocarbonyl, carboxy, alkoxycarbonyl and cyano; j) (cycloalkyl) alkyl, wherein the cycloalkyl is unsubstituted or substituted with one or more substituents, each independently selected from the group consisting of alkyl, alkoxy, halogen, haloalkyl, haloalkoxy, hydroxy, hydroxyalkyl, amino, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, aminocarbonyl, carboxy, alkoxycarbonyl and cyano; k) aryl, unsubstituted or substituted with one or more substituents, each independently selected from the group consisting of alkyl, alkoxy, halogen, haloalkyl, haloalkoxy, hydroxy, hydroxyalkyl, amino, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, aminocarbonyl, carboxy, alkoxycarbonyl and cyano; l) arylalkyl, wherein the aryl group is unsubstituted or substituted with one or more substituents, each independently selected from the group consisting of alkyl, alkoxy, halogen, haloalkyl, haloalkoxy, hydroxy, hydroxyalkyl, amino, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, aminocarbonyl, carboxy, alkoxycarbonyl and cyano; m) heteroaryl, unsubstituted or substituted with one or more substituents, each independently selected from the group consisting of alkyl, alkoxy, halogen, haloalkyl, haloalkoxy, hydroxy, hydroxyalkyl, amino, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, aminocarbonyl, carboxy, alkoxycarbonyl and cyano; n) heteroarylalkyl, wherein the heteroaryl group is unsubstituted or substituted with one or more substituents, each independently selected from the group consisting of alkyl, alkoxy, halogen, haloalkyl, haloalkoxy, hydroxy, hydroxyalkyl, amino, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, aminocarbonyl, carboxy, alkoxycarbonyl and cyano; o) heterocycle, unsubstituted or substituted with one or more substituents, each independently selected from the group consisting of alkyl, alkoxy, halogen, haloalkyl, haloalkoxy, hydroxy, hydroxyalkyl, amino, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, aminocarbonyl, carboxy, alkoxycarbonyl and cyano; op) heterocycloalkyl, wherein the heterocycle is unsubstituted or substituted with one or more substituents, each independently selected from the group consisting of alkyl, alkoxy, halogen, haloalkyl, haloalkoxy, hydroxy, hydroxyalkyl, amino, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl , aminocarbonyl, carboxy, alkoxycarbonyl and cyano.