Oxyindole derivatives with motilin receptor agonist activity

摘要

A compound of the following formula (I): ** Formula ** wherein R1 is independently selected from the group consisting of hydrogen, C1-C4 alkyl, and C3-C7 cycloalkyl; R2 is independently selected from the group consisting of C1-C4 alkyl and C3-C7 cycloalkyl; or, alternatively, R1 and R2, together with the atoms to which they are attached, form a 3- to 6-membered ring that can contain oxygen; R3 and R4 are independently hydrogen or C1-C4 alkyl; R5 is hydrogen or C1-C4 alkyl; R6 and R7 are independently selected from hydrogen, C1-C4 alkyl, and C1-C4 alkoxy, C1-C4 alkyl; or, alternatively, R6 and R7 together with the nitrogen atom to which they are attached form a 4- to 6-membered ring that can contain nitrogen or oxygen, wherein the 4- to 6-membered ring is optionally substituted with 1 to 4 substituents independently selected from the group consisting of C 1 -C 4 -alkyl, amino, C 1 -C 4 -alkylamino and di (C 1 -C 4 -alkyl) amino; ** Formula ** A is where p, q and r are independently 0 , 1 or 2; R8 and R9 are independently hydrogen or C1-C6 alkyl; said alkyl is optionally substituted with hydroxy, C1-C4-alkyl, amino, C1-C4-alkylamino and di (C1-C4-alkyl) amino; or R8 and R9 can be linked together to form a ring of C3-C7 members; or R8 and R9 can independently bind one or both of the R8 and R9 groups to form alkylene bridges between the terminal nitrogen and the alkyl portion of the R8 or R9 groups, wherein the bridge contains 1 to 5 atoms carbon; said bridge is optionally substituted with from 1 to 4 of C1-C4 alkyl; W is N-R10, said R10 is hydrogen or C1-C4 alkyl; X is C0-C4 alkylene or C0-C4-alkylene-C0-C4 alkylene, where K is -O-; said alkylene is optionally substituted with C1-C4 alkyl; Y is hydrogen or a 5-10 membered ring; said ring is optionally substituted with hydroxy, halogen, C1-C4 haloalkyl, C1-C4 alkyl or C1-C4 alkoxy; when X is C0, Y is not hydrogen; Z is halogen or C1-C4 alkyl; m is 0, 1, 2, 3 or 4; n is 0, 1 or 2; or a pharmaceutically acceptable salt thereof.