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A NOVEL RECEPTOR TREM(TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS) AND USES THEREOF
A NOVEL RECEPTOR TREM(TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS) AND USES THEREOF
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机译:一种新的受体TREM(在髓样细胞上表达的触发受体)及其用途
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摘要
Novel activating receptors of the Ig super-family expressed on human myeloid cells, called TREM(s)(triggering receptor expressed on myeloid cells) are provided. Specifically, two (2) members of TREMs, TREM-1 and TREM-2 are disclosed. TREM-1 is a transmembrane glycoprotein expressed selectively on blood neutrophils and a subset of monocytes but not on lymphocytes and other cell types and is upregulated by bacterial and fungal products. Use of TREM-1 in treatment and diagnosis of various inflammatory diseases are also provided. TREM-2 is also a transmembrane glycoprotein expressed selectively on peripheral deindritic cells (DCs) but not on granulocytes or monocytes. DC stimulation via TREM-2 leads to DC maturation and resistance to apoptosis, and induces strong upregulation of CCR7 and subsequent chemotaxis toward macrophage inflammatory protein 3- .beta. TREM-2 has utility in modulating host immune responses in various immune disorders, including autoimmune diseases and allergic disorders
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