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METHOD FOR THE PRODUCTION OF A CELL AND/OR TISSUE AND/OR DISEASE PHASE SPECIFIC MEDICAMENT

机译:细胞和/或组织和/或疾病阶段专用药物的生产方法

摘要

The present invention relates to a method for producing of a cell and/or tissue and/or disease phase specific medicament against chronic inflammatory diseases. Disease, cell type, tissue and/or stage specific proteins and nucleic acids are identified with regard to their modified expression pattern and the corresponding nucleic acids are analyzed as possible attack targets for DNAzymes or siRNA. What follows is a design of active specific DNAzymes and siRNA which bind to the target sequence and cleave it such that a medicament against chronic inflammatory diseases and autoimmune diseases is provided.
机译:本发明涉及一种生产针对慢性炎性疾病的细胞和/或组织和/或疾病阶段特异性药物的方法。就其修饰的表达模式鉴定疾病,细胞类型,组织和/或阶段特异性蛋白质和核酸,并分析相应的核酸作为DNAzyme或siRNA的可能攻击靶标。接下来是与靶序列结合并对其进行切割的活性特异性DNA酶和siRNA的设计,从而提供了针对慢性炎性疾病和自身免疫性疾病的药物。

著录项

  • 公开/公告号CA2776997C

    专利类型

  • 公开/公告日2015-05-19

    原文格式PDF

  • 申请/专利权人 STERNA BIOLOGICALS GMBH & CO. KG;

    申请/专利号CA20042776997

  • 发明设计人 SEL SERDAR;RENZ HARALD;

    申请日2004-10-01

  • 分类号C12N9/22;C12N5/07;C12N15/113;C12N15/11;

  • 国家 CA

  • 入库时间 2022-08-21 15:11:31

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