METHODS FOR THE STABILIZATION OF ARTERIAL PLAQUE FOR THE TREATMENT OF ISCHEMIC STROKE AND PERIPHERAL ARTERY DISEASE

摘要

The present invention relates generally to medical methods. More particularly, the present invention relates to medical methods for delivering in a targeted and reproducible manner, lipid binding agents to the adventitial tissue adjacent to a lipid rich necrotic core in an artery for the prevention and treatment of ischemic stroke and peripheral artery disease. Under the guidance of an external ultrasound probe, an echogenic needle is percutaneously placed in the adventitial layer of an artery whereby a sufficient amount of a lipid binding agent is delivered to rapidly stabilize the lipid rich necrotic core of the targeted artery. Such delivery amount and location are sufficient to at least partially delipidate the lipid rich necrotic core.