Methods of treating cancer using angiogenin or an angiogenin agonist

摘要

#$%^&*AU2013204740C120151001.pdf#####(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2013/166555 Al 14 November 2013 (14.11.2013) W I P 0 I P C T (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, A61K38/17(2006.01) A61P 35/00 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, C07K14/515 (2006.01) DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, (21) International Application Number: KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, PCT/AU2013/000478 ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, (22) International Filing Date: NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, 10 May 2013 (10.05.2013) RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, (25) Filing Language: English ZM, Zw. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 2012901918 10 May 2012 (10.05.2012) AU GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, 2013204740 12 April 2013 (12.04.2013) AU UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (71) Applicant: MURRAY GOULBURN CO-OPERATIVE EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, CO. LIMITED [AU/AU]; Freshwater Place, Level 15, 2 MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, Southbank Boulevard, Southbank, Victoria 3006 (AU). TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (72) Inventors: HOBMAN, Peter; 164/299 Queen Street, Mel- ML, MR, NE, SN, TD, TG). bourne, Victoria 3000 (AU). BROWN, Andrew; 64 Published: Wondah Street, Cobram, Victoria 3644 (AU). - with international search report (Art. 21(3)) (74) Agent: GRIFFITH HACK; GPO Box 1285, Melbourne, - with amended claims (Art. 19(1)) Victoria 3001 (AU). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (54) Title: METHODS OF TREATING CANCER USING ANGIOGENIN OR AN ANGIOGENIN AGONIST 0.8 Figure 1 - 0.6 0.4 T -Control E- 60ug S0.2 - 300ug 0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 -0.2 Day (57) Abstract: The invention provides a method for treating cancer in a subject or a method of inducing an anti-tumour effect ino eluding reducing tumour volume, inhibiting or slowing tumour growth, inhibiting tumour progression, altering the metabolic activity of a tumour, inducing quiescence of a tumour, inhibiting or reducing metastasis, inhibiting or reducing tumour invasiveness, redu cing tumour weight, reducing tumour neovascularisation, improving time to disease progression (TDP) and/or improving survival, the method comprising administering to the subject an effective amount of angiogenin or an angiogenin agonist.