BIOMARKERS AND USE THEREOF IN IDENTIFICATION OF B-CELL LYMPHOPROLIFERATIVE DISORDERS

摘要

A method of determining whether or not a subject has a B-cell lymphproliferative disorder, includes determining the expression, level of one or more of miRNA.-l.973., rni.RNA.-638 and tmRNA-494, wherein a B-cell lymphoproiiferative disorder is associated with elevated levels of the miRNAs. Measurement of expression levels of these miRNAs may he useful in a method of evaluating treatment eftlcacy of a B-cell lymphproliferative disorder, a method of treating a B-cell lymphoproliferative disorder and/or a method of determining the prognosis of a subject with a B-cell lymphoproliferative disorder. Examples of B-cell lymphproliferative disorders include Diffuse large B-cell lymphoma, follicular lymphoma, chronic lymphocytic leukemia, mantle cell lymphoma, classical Hodgkin Lymphoma and Burkitt lymphoma.