CORE-SHELL FLUORESCENT UPCONVERSION NANOPARTICLES FOR PHOTOACTIVATION OF MULTIPLE BIOMOLECULES

摘要

The invention provides, inter alia, upconversion nanoparticles (UCN) configured for near infrared (NIR) light excitation and ultraviolet (UV) light emission, visible light emission, or UV and visible light emission and compositions containing them. The invention also provides methods of making and using these UCNs, e.g., for delivery and photoactivation of target compounds, imaging biological tissues, and methods of treatment, e.g., of cancers, such as melanoma, by delivering chemotherapeutic agents, such as taxanes.