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PHARMACEUTICAL COMPOSITION COMPRISING A SOLID DISPERSION WITH A POLYMER MATRIX CONTAINING A CONTINUOUS POLYDEXTROSE PHASE AND A CONTINUOUS PHASE OF A POLYMER OTHER THAN POLYDEXTROSE
PHARMACEUTICAL COMPOSITION COMPRISING A SOLID DISPERSION WITH A POLYMER MATRIX CONTAINING A CONTINUOUS POLYDEXTROSE PHASE AND A CONTINUOUS PHASE OF A POLYMER OTHER THAN POLYDEXTROSE
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机译:包含固体分散体和包含连续聚合物连续相以及聚合物以外的聚合物连续相的固体分散体的药物组合物
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摘要
The invention relates to a solid pharmaceutical composition comprising a solid dispersion containing at least one active principle and a pharmaceutically-acceptable polymer matrix. The invention is characterised in that the pharmaceutically-acceptable polymer matrix comprises a mixture of (i) polydextrose, in the form of a continuous polydextrose phase, in order to favour the disintegration of the composition in an aqueous medium and (ii) at least one polymer other than polydextrose, in the form of a continuous phase, whereby the polydextrose is in a concentration of at least 20 wt.- % and the at least one polymer other than polydextrose is in a concentration of at least 20 wt.- % in relation to the total weight of the pharmaceutically-acceptable polymer matrix.
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