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TUMORSPECIFIC PET/MR(T1), PET/MR(T2) AND PET/CT CONTRAST AGENT
TUMORSPECIFIC PET/MR(T1), PET/MR(T2) AND PET/CT CONTRAST AGENT
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机译:肿瘤PET / MR(T1),PET / MR(T2)和PET / CT造影剂
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摘要
New types of nanoparticle-based dual-modality positron emission tomography/magnetic resonance imaging (PET/MRI) and positron emission tomography/computed tomography (PET/CT) tumorspecific contrast agents have been developed. The base of the new type contrast agents is biopolymer-based nanoparticle with PET, MRI and CT active ligands. The nanoparticle contains at least one polyanion and polycation, which form nanoparticles via ion-ion interaction. The self-assembled polyelectrolytes can transport gold nanoparticles as CT contrast agents, or SPION or Gd(III) ions as MRI active ligands, and are labeled using a complexing agent with gallium as PET radiopharmacon. Furthermore, these dual modality PET/MRI and PET/CT contrast agents are labeled with targeting moieties to realize the tumorspecificity.
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