Non-aqueous single phase biocompatible viscous vehicles and methods for preparing the same

摘要

There is disclosed a non-aqueous single phase biocompatible viscous vehicle capable of suspending a beneficial agent and dispensing the beneficial agent over an extended period of time at body temperature. The vehicle comprises solvent, surfactant, and polymer. The solvent, surfactant and polymer are not the same. The solvent is lauryl alcohol or lauryl lactate, the surfactant is selected from the group consisting of esters of polyhydric alcohols, ethoxylated castor oil, polysorbates, esters or ethers of saturated alcohols, and polyoxyethylenepolyoxypropylene block copolymers, and the polymer is selected from the group consisting of polyesters, pyrrolidones, esters or ethers of unsaturated alcohols, and polyoxyethylenepolyoxypropylene block copolymers.