METHODS OF TREATING DISEASES BY MODULATING MITOCHONDRIAL DNA DELETIONS

摘要

Disclosed herein are methods for controlling the level of mitochondrial DNA deletions and particularly the "common deletion" (CD) or the "4977bp deletion" in the mitochondria of cells. The control of CD is achieved by regulating the activity of sirtuin in cells for treating age-related human diseases or for treating diseases that exhibit uncontrolled growth or to produce stem cells suitable for personalized regenerative medicine or for testing therapeutic drugs.