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Fusion constructs and use of same to produce antibodies with increased FC receptor binding affinity and effector function
Fusion constructs and use of same to produce antibodies with increased FC receptor binding affinity and effector function
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机译:融合构建体及其用于产生具有增加的FC受体结合亲和力和效应子功能的抗体的用途
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摘要
The present invention relates to the field of glycosylation engineering of proteins. More particularly, the present invention relates to nucleic acid molecules, including fusion constructs, having catalytic activity and the use of same in glycosylation engineering of host cells to generate polypeptides with improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function.
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