APPLICATION OF DEUTERATED FUMARIC ACID DERIVATIVES IN TREATMENT OF MULTIPLE SCLEROSIS

摘要

The present invention relates to the application of a deuterated fumaric acid derivative selected from the following group in the preparation of a drug for the treatment or prevention of multiple sclerosis: 2,3-dideuterio- or 2-deuterio- or 3-deuterio-dialkyl fumarate, 2,3-dideuterio- or 2-deuterio- or 3-deuterio-monoalkyl hydrogen fumarate, 2,3-dideuterio- or 2-deuterio- or 3-deuterio-monoalkyl fumarate salts, 2,3-dideuterio- or 2-deuterio- or 3-deuterio-monoamide fumarate, 2,3-dideuterio- or 2-deuterio- or 3-deuterio-monoamide fumarate salts, 2,3-dideuterio- or 2-deuterio- or 3-deuterio-diamide fumarate, and 2,3-dideuterio- or 2-deuterio- or 3-deuterio-monoalkyl monoamido fumarate, as well as mixtures of these compounds. These applications are based on findings that deuterated fumaric acid derivatives activate the Nrf2 cellular pathway within cells.