RIBONUCLEOSIDE ANALOG HAVING AZIDE GROUPS AND METHOD FOR PRODUCING SAME, AND CHIMERA-TYPE OLIGORIBONUCLEOTIDE ANALOG CONTAINING TRIAZOLE LINKING-TYPE OLIGORIBONUCLEOTIDE FORMED FROM SUCH ANALOG

摘要

Provided is a means for producing a non-natural nucleoside analog in which position 5 is a hydroxyl group and which is for synthesizing a triazole linking-type non-natural nucleotide having a structure bonded via organic groups containing 1,2,3-triazole rings. The present invention is related to a method for producing a compound represented by formula (Ic) (in the formula, each X is independently selected from a purine base and a pyrimidine base, and PG² and PG⁵ are each independently hydrogen or a protector group) wherein, the method includes performing 3β-azidation of the 3α-hydroxyl of D-xylose using D-xylose as the starting material, and bonding the purine base or pyrimidine base at position 1.