首页> 外国专利> PRODUCTION METHOD OF POLYPEPTIDE USING OLIGO RIBONUCLEOTIDE ANALOG CONTAINING TRIAZOLE LINKING-TYPE OLIGORIBONUCLEOTIDE

PRODUCTION METHOD OF POLYPEPTIDE USING OLIGO RIBONUCLEOTIDE ANALOG CONTAINING TRIAZOLE LINKING-TYPE OLIGORIBONUCLEOTIDE

机译:含三唑键合型寡核苷酸的寡核糖寡核苷酸类似物的多肽生产方法

摘要

PROBLEM TO BE SOLVED: To provide means for producing a polypeptide with high efficiency using an artificial nucleic acid as a template of a translation reaction.SOLUTION: The present invention relates to a production method of a polypeptide comprising the following: a template preparation step of preparing an oligoribonucleotide analog comprising a triazole linking-type oligoribonucleotide having a nucleic acid sequence corresponding to an amino acid sequence of the polypeptide; and a polypeptide synthesis step of synthesizing the polypeptide using the oligoribonucleotide analog prepared in the template preparation step as a template.SELECTED DRAWING: None
机译:解决的问题:提供使用人工核酸作为翻译反应的模板高效生产多肽的方法。解决方案:本发明涉及一种多肽的生产方法,包括以下步骤:模板制备步骤制备包含三唑连接型寡核糖核苷酸的寡核糖核苷酸类似物,所述三唑连接型寡核糖核苷酸具有对应于所述多肽的氨基酸序列的核酸序列;以及使用在模板制备步骤中制备的寡核糖核苷酸类似物作为模板来合成多肽的多肽合成步骤。

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