Synthesis and properties of oligoribonucleotide analogs having formacetal internucleoside linkages

摘要

The posssibility to use short oligonucleotides as thera- peutic agents has recently received much attention. To be efficient, such antisense agents should exhibit high enzymatic stability while retaining binding affinity and specificity to the intracellular target, usually a messenger RAN. Unmodified oligonucleotides are readily degraded By nucleases and, thus, are poor antisense compounds.