Pharmaceutical Compositions for Preventing or Treating Autoimmune Diseases Comprising Mesenchymal Stem Cells Derived from Human Bone-Marrow

摘要

In the present invention, provided is a pharmaceutical composition for treating or preventing autoimmune diseases, including mesenchymal stem cells derived from bone marrow as an active ingredient, wherein the mesenchymal stem cells derived from bone marrow plays roles in inhibiting generation of anti-dsDNA antibodies, proteinuria and total IgG without any toxicity, the proliferation of T cells and B cells and expression of cytokines in T cells, thereby having effects of preventing or treating autoimmune diseases. In the present invention, systemic lupus erythematosus is inflammation in the kidney by autoantibody and immune complex and immunocyte infiltration is increased in systemic lupus erythematosus. When mesenchymal stem cells derived from bone marrow of the present invention are administered, systemic lupus erythematosus is prevented or treated by reducing immunocyte infiltration.