首页> 外国专利> AZAINDOLE DERIVATIVES, C-KIT INHIBITORING COMPOSITION AND PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF DISEASES LINKED TO C-KIT COMPRISING THE SAME

AZAINDOLE DERIVATIVES, C-KIT INHIBITORING COMPOSITION AND PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF DISEASES LINKED TO C-KIT COMPRISING THE SAME

机译:氮杂吲哚衍生物,C-KIT抑制组合物和药物组合物,用于治疗与C-KIT相关的疾病

摘要

The present invention relates to an azaindole derivative compound represented by chemical formula 1, a c-kit D816V mutant comprising the same as an active ingredient and c-kit wild type (WT) inhibitor composition. A composition according to the present invention can efficiently inhibit expression of a c-kit D816V mutant as well as a c-kit WT and thus can be used for treating a c-kit D816V mutant and a c-kit WT-related diseases, especially, cancer.
机译:本发明涉及由化学式1表示的氮杂吲哚衍生物化合物,包含其作为活性成分的c-kit D816V突变体和c-kit野生型(WT)抑制剂组合物。根据本发明的组合物可以有效抑制c-kit D816V突变体以及c-kit WT的表达,因此可以用于治疗c-kit D816V突变体和与c-kit WT相关的疾病,特别是,癌症。

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