A mutant of Neurospora crassa L-arabitol dehydrogenase improved in activity

摘要

The invention newooro Castello La Chrysler Corporation using quantum mechanics and molecular dynamics techniques and partial mutation techniques ( Neurospora crassa ) is to increase the stability and activity of enzymes derived from L- arabitol dehydrogenase. More specifically , looking at the quantum mechanics , and residues that affect the enzyme stability through screening based on molecular dynamics , by mutation of the enzyme activity is improved navigation residue L- arabitol dehydrogenase , nucleic acid molecules coding them , the vector comprising a nucleic acid molecule , a transformant containing the vector , to a method for producing a mutant wherein the L- and improved L- arabitol dehydrogenase of arabitol dehydrogenase . ;