novel beta -substituted Morita - Bailey - Hillman derivatives

摘要

This invention relates to beta-substituted represented by the formula (1) Morita-Bailey-Hillman derivative, a pharmaceutically acceptable salt thereof, relates to a hydrate, solvate and stereoisomer thereof, wherein the derivative using a carbonyl compound, or a variety of different aldehyde or ketone, such as migration in the presence of a Lewis acid-beta-iodo- Morita-Bailey-Hillman ester the manufacture, and, as a basic skeleton, and it may be prepared by replacing the vinyl iodide in the position of various substituents. In addition, the present invention according to the substitution Morita beta-Bailey-Hillman derivatives have excellent pharmacological effects such as anti-cancer effect ; [Formula 1] ; img id = "1". file = "112008016502635-pat00001.jpg" wi = "39" he = "36" img-format = "jpg" / ; Morita - Bailey - Hillman added Water derivatives, propionic oleate, aldol, receive, iodide, Sequoia Mall coat Ride A