Composition for maturation of dendritic cell comprising Polysaccharide isolated from platycodon gradiflorum

摘要

The present invention relates to a composition for inducing maturation of dendritic cells, a method for maturing dendritic cells using the same, and a pharmaceutical composition for treating cancer comprising matured dendritic cells prepared by the method as an active ingredient. The polysaccharide derived from Gakyung according to the present invention stimulates TLR (toll-like receptor) -4 to mature dendritic cells through MAPK signal pathway and NF-κB activation and increases nitric oxide production by dendritic cell maturation; Increase of surface molecule expression; Increase of inclusion action; Increased cytokine secretion; Increased expression of signaling molecules activated during maturation; And T cell activation activity. Therefore, the composition of the present invention comprising the Gakugein-derived polysaccharide as an active ingredient of the present invention can be used for inducing or promoting maturation of dendritic cells. In addition, the mature dendritic cells prepared using the Gakugein-derived polysaccharide of the present invention can effectively be used as a cell therapy agent for preventing or treating diseases such as cancer, in which the function of dendritic cells is decreased as the immune response is effectively increased .