Method for production of codon-optimized intact and N-terminal truncated Noda Capsid Protein in the Yeast Yarrowia lipolytica for recombinant vaccine development

摘要

The present invention relates to a recombinant expression vector for expressing a Nodavirus capsid protein in Yarrowia lipolytica , a transformed Y. lipolytica strain into which the recombinant expression vector has been introduced, A method for producing a capsid protein of Nodavirus, and a vaccine composition comprising the Nodavirus capsid protein separated from the cell, culture, or the like. According to the present invention, it is possible to economically provide a safe vaccine against Nodavirus by mass-producing nodavirus capsid protein using a yeast yeast lipolytica expression system with proven stability, .