METHOD FOR PREPARING (R)-ROLIPRAM PRECURSOR BY CATALYTIC ASSYMETRIC MICHAEL REACTION AND METHOD FOR PREPARING (R)-ROLPTRAM USING SAME

摘要

According to the present invention, a method for preparing chiral (R)-rolipram precursors includes a step of enabling an asymmetric Michael reaction of 3-(cyclo pentoxy)-4-methoxyphenyl nitro and malonate in the presence of a soluble chiral catalyst. Accordingly, the present invention can synthesize chiral (R)-rolipram precursors at low costs by using an organic catalyst not including transition metals with high optical selectivity and reactivity in the presence of water, aqueous solution, or a mixed solution of an organic solvent which are not harmful to the human body and do not cause environmental pollution.;COPYRIGHT KIPO 2015