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DIRECT CONVERSION METHOD OF SOMATIC CELLS TO DOPAMINERGIC NEURON USING DRUG INDUCIBLE SYSTEM
DIRECT CONVERSION METHOD OF SOMATIC CELLS TO DOPAMINERGIC NEURON USING DRUG INDUCIBLE SYSTEM
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机译：药物诱导系统将体细胞直接转化为多巴胺能神经元的方法
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摘要
The present invention relates to a direct conversion method of somatic cells to dopaminergic neuron using a drug inducible system. According to the present invention, a direct conversion method of somatic cells to dopaminergic neuron comprises the steps of: manufacturing a chimeric animal from embryonic stem cells internalized with transcription factors of Ascl1, Pitx3, Nurr1, and Lmx1a; separating somatic cells from the chimeric animal; and inducing dopaminergic neuron by culturing the somatic cells in a medium containing doxycycline.;COPYRIGHT KIPO 2015
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