Tumor cells undergoing direct lineage conversion to neurons：unnatural but useful?

摘要

Dear Editor,In 2011,Son et al.(2011)reported that the forced expression of selected transcription factors is sufficient to convert mouse and human fibroblasts into induced motor neurons(i MNs).The authors used three factors(Ascl1,Brn2,and Myt1l)to convert fibroblasts into neuronal-like cells.After confirming that the cells had neuronal morphology。