首页> 外国专利> EXPRESS METHOD OF OBTAINING RESTORED FORM OF COFERMENT Q ON TO THE BASIS CATALYSTS FOR USE B PHARMACEUTICAL AND FOOD COMPOSITIONS

EXPRESS METHOD OF OBTAINING RESTORED FORM OF COFERMENT Q ON TO THE BASIS CATALYSTS FOR USE B PHARMACEUTICAL AND FOOD COMPOSITIONS

机译:在B类药品和食品成分的基础催化剂上获取还原形式的交易Q的快速方法。

摘要

1. A method for producing reduced coenzyme Qvklyuchaet coinciding with the method of US 2011123505 (A1) a step (i) prior dissolution in ethanol, ascorbic acid and oxidized form of coenzyme Q, but combined in a molar ratio of at least 5: 1, characterized in that it includes the further sequential steps of : (ii) the addition of trace catalyst - Cuv ions as copper sulfate pentahydrate solution (CuSO · 5HO); (Iii) catalytic reduction coenzyme Qc form its reduced form (ubiquinol); (Iv) crystallization and isolating the final product - the reduced coenzyme Qc vodoy.2 its subsequent washing. A method according to claim 1, characterized in that in step (i) using 95% solvent etanol.3. A method according to claim 1, characterized in that after evaporating off the ethanol may be recovered for subsequent ispolzovaniya.4. A method according to claim 1, characterized in that in step (iii) catalytic reduction proceeds Coenzyme Q (ubiquinone) quantitatively at 25 ° C.5. A method according to claim 1, characterized in that the amount of the final product is increased 4-5 times when coenzyme Qprovoditsya catalytic reduction at 60 ° C.6. A method according to claim 1, characterized in that in step (iv) in the resulting solution was retreaded coenzyme Qdobavlyayut 10 vol.% Vody.7. A method according to claim 1, characterized in that selected in step (iv) reduced coenzyme Qmozhet be stabilized ascorbic acid (weight ratio KoQ:. AK 1: 1) in an aqueous solution by introducing a solubilizer and then receiving a gel containing 10% the reduced coenzyme KoQ.8. A method according to claim 1, characterized in that selected in step (iv) reduced coenzyme hundred be Qmozhet
机译:1.一种生产还原型辅酶Qvklyuchaet的方法,该方法与US 2011123505(A1)的方法一致,步骤(i)在将乙醇,抗坏血酸和氧化形式的辅酶Q溶解之前,但以至少5:1的摩尔比组合,其特征在于它包括进一步的后续步骤:(ii)加入痕量催化剂-Cuv离子的五水合硫酸铜溶液(CuSO·5HO); (I)催化还原型辅酶Qc以其还原形式(泛醇); (iv)结晶并分离出最终产物-还原的辅酶Qcvodoy。2其随后的洗涤。 2.根据权利要求1的方法,其特征在于在步骤(i)中使用95%溶剂乙醇。 2.根据权利要求1所述的方法,其特征在于,蒸发掉乙醇后,可以将其回收用于随后的ispolzovaniya。 2.根据权利要求1所述的方法,其特征在于,在步骤(iii)中,催化还原在25℃下定量进行辅酶Q(泛醌)5。 2.根据权利要求1所述的方法,其特征在于,当辅酶Qprovoditsya在60℃催化还原时,最终产物的量增加4-5倍6。 2.根据权利要求1所述的方法,其特征在于,在步骤(iv)中,将所得溶液中的辅酶Qdobavlyayut Qdobavlyayut 10体积%Vody.7翻新。 2.根据权利要求1所述的方法,其特征在于,在步骤(iv)中选择的还原型辅酶Qmozhet是通过引入增溶剂然后接受包含10%的凝胶的水溶液来稳定化的抗坏血酸(重量比KoQ:.AK1:1)。还原型辅酶KoQ.8。 2.根据权利要求1所述的方法,其特征在于,在步骤(iv)中选择的还原型辅酶为Qmozhet

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