SOLUTION FOR PRIMARY FILLING OF THE ARTIFICIAL BLOOD CIRCULATION APPARATUS

摘要

1. A solution for the initial filling of the cardiopulmonary bypass apparatus, including a balanced saline solution and a combination of oncotic and neoncotic dextran molecules, for use to maintain oncotic pressure during the cardiopulmonary bypass, where the oncotic dextran molecule has an average molecular weight of 35 to 45 kDa, and the neoncotic dextran molecule has an average molecular weight of less than 5 kDa, and where oncotic dextran is present in a concentration equivalent to between 35 and 55 g / l of dextran 40, and neoncotic dextran is present in a concentration equivalent to 1 to 10 g / l of dextran 1.2. The initial filling solution according to claim 1, characterized in that the oncotic dextran is a dextran 40.3. A solution for initial filling according to any one of the preceding paragraphs, characterized in that the neoncotic dextran is a dextran 1.4. The primary filling solution according to claim 3, characterized in that the concentration of dextran 1 is from 1 to 5 g / l. The use of the solution for the initial filling of the cardiopulmonary bypass apparatus according to paragraphs. 1 - 4 in the method of cardiopulmonary bypass. 6. A method for maintaining the patient's oncotic pressure during the cardiopulmonary bypass procedure, comprising bringing the patient into contact with the solution according to any one of paragraphs 1 to 4.7. The method according to claim 6, characterized in that the patient is a human. The combination of a solution for the primary filling of the cardiopulmonary bypass apparatus according to any one of paragraphs. 1 - 4 and cardiopulmonary bypass.