A method of predicting rapid virologic response in patients with chronic hepatitis C

摘要

A method of predicting rapid virological response in patients with chronic hepatitis C in patients comprising the determination of an allelic variant of IL-28B gene and carrying out an immunological test, characterized in that the presence of allele rsl2979860CC / rs8099917TT coefficient is calculated ImmunoPrognozirovaniya 1 (KIP1) by the formula: = 2,774- KIP1 0,833 · [CD3 +] - 0,016 · [CD4 +] - 0,063 · [CD8 +] - 0,525 · [CD19 +], where [CD3 +] - absolute content of CD3 + cells in 1 liter of blood, [CD4 +] - absolute content of CD3 + / CD4 + cells in 1 l blood, [CD8 +] - absolute content of CD3 + / CD8 + cells in 1 liter of blood, [CD19 +] - absolute containing of CD19 + cells in 1 liter of blood, at a value which is 1.5 predict the development of rapid viral response to therapy with pegylated interferon α and ribavirin, a 1.5 - its absence; in the presence of any other allelic variant is calculated KIP2 formula: KIP2 = 3,994 + 0,014 · [CD56 + / ki-67 +] - 0,408 · [CD25hi] -0,69 · [CD25hi / FoxP3 +], where [CD56 + / ki-67 + ] - the percentage of CD16 + / CD56 + / ki-67 + cells in blood lymphocytes, [CD25hi] - the percentage of CD3 + / CD25high cells in blood lymphocytes, [CD25hi / FoxP3 +] - the percentage of CD3 + / CD25high / FoxP3 + cells in blood lymphocytes in which the value of 3.0 predict the development of rapid viral response to therapy with pegylated interferon α and ribavirin, a 3.0 - its absence.