PHARMACEUTICAL COMPOSITIONS CONTAINING A WATER-Insoluble ANTipsychotic PRODUCT AND SORBITE COMPLEXES

摘要

1. A pharmaceutical composition comprising (a) a water-insoluble antipsychotic agent; (b) esters of sorbitol and carboxylic acid, where the carboxylic acid contains 4-20 carbon atoms; (c) a polyoxyethylene derivative of esters of sorbitol and carboxylic acid, where the carboxylic acid contains 8 -14 carbon atoms; and (d) an aqueous filler; where the composition forms an aqueous, flocculated, injectable suspension. The pharmaceutical composition according to claim 1, wherein the water-insoluble antipsychotic is aripiprazole, a compound of formula 1 or a compound of formula II, or pharmaceutically acceptable salts thereof, hydrates or solvates of which R is absent and R is —CHOC (O) R, —CHOC (O) OR, —CHOC (O) N (R) or —C (O) R; or R is absent and R is —CHOC (O) R, —CHOC (O) OR, —CHOC (O) N (R) or —C (O) R; R is —CHOC (O) R, —CHOC (O) OR, —CHOC (O) N (R) or —C (O) R; where each R is independently selected from the group consisting of hydrogen, substituted or unsubstituted aliphatic groups and substituted or ezameschennogo aryl; where each R is selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl; wherein is a pharmaceutically acceptable counterion; it is a single or double bond. 3. The pharmaceutical composition according to any one of the above items, wherein the water-insoluble antipsychotic agent is compound A-4 or compound A-74. The pharmaceutical composition according to claim 1, wherein the water-insoluble antipsychotic is olanzapine, a compound of formula III or a compound of formula IV, or pharmaceutically acceptable salts thereof, hydrates or solvates of which are R