A method for diagnosing occlusive vascular lesions in patients with heart disease

摘要

A method for diagnosing occlusive lesions vessels in patients with cardiovascular diseases, characterized by determining the level of total homocysteine ​​in the blood, the presence of mutations polymorphism C677T in the gene for methylenetetrahydrofolate reductase Leydenovskoy G1691A mutation in the Factor V gene mutation polymorphism 675 4G / 5G in the inhibitor gene I-type plasminogen activator and take into account the patient's age, then discriminant function value calculated by the formula: D = 0,531 × B-15,466 × MTHFR + 19,0338 · FV Leiden + 0,9814 · (PAI-1) + 0.89 · oGtsi- 18.266, where B - the patient's age, years; MTHFR - Muta Ia polymorphism C677T in the gene for methylenetetrahydrofolate reductase: 0 - normal, 1 - heterozygote for a mutation, 2 - homozygote for the mutation; FV Leiden - Leydenovskaya G1691A mutation in the Factor V gene: 0 - normal, 1 - heterozygote for a mutation, 2 - homozygote for the mutation ; PAI-1 - 675 polymorphism mutation 4G / 5G in the gene of plasminogen activator inhibitor type I: 0 - normal, 1 - heterozygote for a mutation of mutations -gomozigota 2; oGtsi - serum total homocysteine, micromoles / liter and a value of D 0 diagnosing the presence of occlusive vascular lesions and, if D 0 -no.