COMPOUNDS FOR PURPOSED DELIVERY OF MEDICINES AND STRENGTHENING OF SIPHK

摘要

1. The compound of formula I where R and R are independently selected from the group consisting of a C-Calkyl, C-Calkenyl and oleyl group; where R and R are independently selected from the group consisting of C1-6 alkyl and alkanol; where X is selected from the group consisting of —CH—, —S— and —O— or is absent; where Y is selected from - (CH), -S (CH), -O (CH) -, thiophene, -SO (CH) - and an ester, where n = 1-4; where a = 1-4; where b = 1-4; where c = 1-4; and where Z is the counterion. 2. A compound according to claim 1, wherein the counterion is halogen or mesylate. 3. A compound according to claim 1, which is selected from the group consisting of 4. A stellar cell-specific drug carrier containing a stellar-cell-specific amount of a retinoid molecule and a cationic lipid consisting of a compound according to claim 3.5. A drug carrier according to claim 4, further comprising a liposome composition. The drug carrier of claim 5, wherein the liposome composition comprises a liposome containing a bilayer of lipid molecules. The drug carrier according to claim 4, wherein the retinoid conjugate is a compound of formula II: wherein q, r and s are each independently 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10; or enantiomer, diastereomer, or a mixture of their stereoisomers. 8. The drug carrier of claim 7, wherein the compound of formula II is 9. The drug carrier of claim 6, wherein the retinoid molecule is at least partially exposed on the outer surface of the drug carrier before the drug carrier reaches the stellate cell. A drug carrier according to claim 4, wherein the retinoid is from 0.2 mol% to 20 mol% of lipid molecules. Drug carrier�