, R1 and R2 are independently selected from the group consistingof C12-C18 alkyl, C12-C18 alkenyl and oleyl group; R3 and R4 are independently selected from the group consisting of C1-C6 alkyl and C2-C6 alkanol; X is selected from the group consisting of -CH2- and -S-, or absent; Y is selected from -(CH2)n and -S(CH2)n , where n is 1 to 4; a=1-4; b=1-4; c=1-4 and Z is a counter ion. The invention also relates to a star-cell-specific drug carrier comprising a star-cell-specific amount of a retinoid molecule and a cationic lipid consisting of a compound of formula I.;EFFECT: improved delivery of therapeutic drugs and increased activity thereof.;31 cl, 16 dwg, 14 tbl, 43 ex"/>
公开/公告号RU2632888C2
专利类型
公开/公告日2017-10-11
原文格式PDF
申请/专利权人 NITTO DENKO KORPOREJSHN;
申请/专利号RU20130158456
发明设计人 SHRIDKHAR K. NEGERAJYAN (US);KARMELI PRIYA (US);NIITSU JOSHIRO (JP);PEJN DZHOZEF I. (US);KHOU DZENG (US);GAUDETTE DZHON A. (US);KNOPOV VIKTOR (US);UITT RICHARD P. (US);AKHMADIAN MUKHAMMED (US);PERELMAN LOREN A. (US);TANAKA YASUNOBU (JP);AKOPYAN VIOLETTA (US);
申请日2012-06-08
分类号C07C237/08;C07C323/41;C07C333/04;A61K9/127;A61K47/18;
国家 RU
入库时间 2022-08-21 13:23:21