COMPOSITIONS AND METHODS FOR DIAGNOSTIC AND MONITORING HYPERTHYROIDISIS IN ANIMAL FAMILY

摘要

1. A method for diagnosing the existence or presence of a high risk of hyperthyroidism in a feline animal, comprising measuring the expression level of one or more biomarkers selected from the group consisting of genes shown in Table A and B; any of IYD, TG, SLC5A5 (NIS), TPO, TSHR, DUOX1 and DUOX2 (ThOX); and their expression products, in a biological sample from the indicated feline animal, where the altered expression of one or more biomarkers in the sample relative to a control expression in the sample from a normal feline animal group or feline group of animals, and / or relative to the previous individual initial value for this an animal feline indicates the existence or high risk of hyperthyroidism. 2. The method according to claim 1a. where one or more biomarkers include IYD, TG, SLC5A5 (NIS), TPO, TSHR, DUOX1, DUOX2 (ThOX), TGFB1 and / or CSTD; or their expression products, and where the increase in the expression of IYD, TG, SLC5A5 (NIS), TPO, TSHR, DUOX1, DUOX2 (ThOX), TGFB1 and / or CSTD; or their expression products in a sample relative to a control expression in a sample from a normal feline animal group or a feline group of animals, and / or relative to a previous individual reference value for that feline animal, indicates the existence or high risk of hyperthyroidism, and / or b. where one or more biomarkers include DCN and / or SEPP1, or their expression products; and where the decrease in the expression of DCN and / or SEPP1 or their expression products in the sample relative to the control expression in the sample from a normal feline or feline, and / or relative