COMPOSITIONS AND METHODS FOR DIAGNOSTIC AND TREATMENT OF HYPERTHYROIDISIS IN ANIMAL COMPANIONS

摘要

1. The selected DNA molecule containing (a) the nucleotide sequence of SEQ ID NO: 1 or (b) a nucleotide sequence that is fully complementary to the nucleotide sequence of SEQ ID NO: 1.2. An isolated DNA molecule containing at least 70 contiguous nucleotides of SEQ ID NO: 1 or at least 70 contiguous nucleotides that are fully complementary to the nucleotide sequence of SEQ ID NO: 1.3. The isolated DNA molecule according to claim 2, wherein 70 contiguous nucleotides are in the coding sequence of the feline sodium iodine symporter protein (NIS protein). An isolated RNAi molecule or an antisense nucleic acid molecule that selectively binds to a nucleic acid molecule according to claim 1.5. An isolated RNAi molecule or an antisense nucleic acid molecule according to claim 4, wherein the RNAi molecule selectively binds to the coding sequence of a cat sodium iodine symporter protein (NIS protein) .6. Isolated protein from 8 to 400 amino acids in length, containing the amino acid sequence of SEQ ID NO: 2.7. An isolated antibody selectively binding to the peptide of SEQ ID NO: 2.8. The antibody of claim 7, wherein the antibody is at least one of a monoclonal, polyclonal, chimeric, single chain, or anti-idiotypic antibody. A cell line, hybridoma, phage, or transgenic organism producing the antibody of claim 7.10. The antibody of claim 7, wherein the antibody is combined with a composition selected from the group consisting of detectable substances and therapeutic agents. A composition comprising the antibody of claim 7 and a pharmaceutically acceptable carrier. The selected antibody fragment according to claim 7, wherein the antibody fragment contains a fragment selected from the group consisting of: a) a Fab fragment; b) F (ab ') fragment and c) Fv fragment. 13. Activity modulation method