BIODEGRADABLE SEMI-CRYSTAL THERMOPLASTIC MULTI-BLOCK COPOLIMERS WITH SEPARATED PHASES FOR CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS

摘要

1. A biodegradable semi-crystalline thermoplastic multiblock separated phase copolymer, characterized in that: a) it contains at least one segment of hydrolyzable prepolymer (A) and at least one segment of hydrolyzable prepolymer (B), b) said multiblock copolymer is characterized by T37 ° C or less and T110-250 ° C under physiological conditions; c) the segments are connected by a multifunctional chain extender; d) the segments are randomly distributed along the polymer chain; e) at least part of the prepolymer segment (A) obtained from a water-soluble polymer. 2. The biodegradable semicrystalline thermoplastic multiblock phase separated copolymer according to claim 1, characterized in that said water-soluble polymer is selected from the group consisting of polyethers such as polyethylene glycol (PEG), polytetramethylene oxide (PTMO) and polypropylene glycol (PPG); polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP), polyvinylcaprolactam, poly (hydroxyethyl methacrylate) (poly- (HEMA)), polyphosphazenes, polyorthoesters, polyorthoesters or copolymers of the above polymers, while the indicated water-soluble polymer (preferably a soluble polymer) PEG) having M150-5000 g / mol. 3. A biodegradable semicrystalline thermoplastic multiblock separated phase copolymer according to claim 1 or 2, characterized in that said chain extender is a bifunctional aliphatic chain extender, preferably a diisocyanate, such as 1,4-butanediisocyanate. 4. Biodegradable semi-crystalline thermoplastic multiblock phase-separated copolymer