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IMMUNOGENIC COMPOSITION FOR TREATMENT OR PREVENTION OF CLOSTRIDIUM DIFFICILE, METHOD OF OBTAINING THEREOF AND METHOD OF INDUCING IMMUNE RESPONSE TO C DIFFICILE
IMMUNOGENIC COMPOSITION FOR TREATMENT OR PREVENTION OF CLOSTRIDIUM DIFFICILE, METHOD OF OBTAINING THEREOF AND METHOD OF INDUCING IMMUNE RESPONSE TO C DIFFICILE
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机译:用于治疗或预防梭菌难治性的免疫原性组合物,获得其的方法和引起对C难治性的免疫反应的方法
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摘要
FIELD: medicine, pharmaceutics.;SUBSTANCE: claimed is immunogenic composition for application in treatment or prevention of disease, associated with Clostridium difficile, method of obtaining said composition by mixing ingredients included into its composition and method of inducing immune response to C. Difficile, which includes introduction of said composition to individual. Claimed composition includes toxin or anatoxin of Clostridium difficile and one or several pharmaceutically acceptable excipients, which contain a) buffer, selected from the group of citrate and phosphate, in concentration from 10-30, 15-25 or 20 mM and b) sugar or sugar alcohol, selected from the group, consisting of sorbitol, trehalose and sucrose in concentration 4-20%.;EFFECT: excipients, which are components of composition, increase stability and/or reduce aggregation of toxins, which makes it possible to obtain compositions more stable in storage with preservation of their conformational integrity.;41 cl, 16 dwg, 13 tbl
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