PRODUCTION OF ALPHA HYDROXY KETONES VIA CARBENE CATALYZED POLE REVERSAL REACTION OF ALDEHYDES

摘要

The present invention relates to the preparation of alpha-hydroxy ketones of the general formula I. In particular, the invention relates to novel imidazolinium carboxylate adducts and to a novel process for using catalytic amounts of imidazolium and imidazolinium carboxylate adducts in the acyloin reaction of aldehydes to prepare hydroxy ketones of the general formula I, where R and R' are the same or different and are each H or a straight-chain or branched and optionally substituted C1-C12-alkyl radical, and R''-H3CSCH2CH2, t-butyl, n-butyl, sec-butyl, n-propyl, i-propyl, an optionally heteroatom-substituted C6-C18-aryl, heteroaryl, C6-C18-arylalkyl, especially phenylmethyl, where phenyl may again be heteroatom-substituted, or heteroalkyl.