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RETROGRADE TRANSPORT VIRAL VECTOR SYSTEM HAVING ENVELOPE COMPRISING FUSED GLYCOPROTEIN
RETROGRADE TRANSPORT VIRAL VECTOR SYSTEM HAVING ENVELOPE COMPRISING FUSED GLYCOPROTEIN
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机译:具有包含融合糖蛋白的包膜的逆转录运输病毒载体系统
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摘要
Provided is a lentiviral vector system which sustains a high-frequency retrograde transportation ability in animal brain and has a higher titer. A kit for preparing a retrograde transport viral vector, which comprises: (1) a packaging plasmid containing the gag gene and pol gene of HIV-1; (2) a packaging plasmid containing an accessory gene of HIV-1; (3) a transfer plasmid containing a target gene; and (4) an envelope plasmid containing, as an envelope gene, a gene encoding a fused polypeptide comprising the extracellular domain of rabies virus glycoprotein (RV-G), the transmembrane domain of rabies virus glycoprotein (RV-G) or vesicular stomatitis virus glycoprotein (VSV-G) and the intracellular domain of vesicular stomatitis virus glycoprotein (VSV-G).
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