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TRANSGENIC MICE FOR THE CONSTANT REGION OF THE G-CLASS HUMAN IMMUNOGLOBULIN HEAVY CHAIN
TRANSGENIC MICE FOR THE CONSTANT REGION OF THE G-CLASS HUMAN IMMUNOGLOBULIN HEAVY CHAIN
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机译:G级人类免疫球蛋白重链恒定区的转基因小鼠
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摘要
The invention relates to a transgenic non-human mammal including an IgH locus modified by the replacement of the switching sequence Sµ with the totality or a portion of the transgene that comprises the gene C? of a G-class human immunoglobulin including at least the exon coding for the CH3 domain and the membrane exons m1 and m2; the invention also relates to the applications thereof in the production of IgG-class humanised antibodies.
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