6-Nitro-2,3-dihydroimidazo 2,1-b oxazole and methods for their preparation

摘要

The present invention relates to a new generation of triazole, tetrazole, isoxazole, urea and sulfonamide functional group-containing 6-nitro-2,3-dihydronitroimidazolox drugs of formula 1, embedded image Or their use as drugs to treat M. tuberculosis, MDR-TB and XDR-TB in combination with other anti-tuberculosis drugs. In the present invention, a new generation of 6-nitro-2,3-dihydronitroimidazooxazole drugs also exhibits acceptable pharmacokinetic properties and synergistic or cumulative effects with known antituberculosis drugs.