Non-invasive method to predict the opioid analgesic and opioid blood levels

摘要

present invention, in patients receiving pain treatment, for example, relates to non-invasive method and apparatus for predicting or monitoring analgesic and blood levels of opioid drug during palliative treatment. The method of the present invention is one or more, preferably a measurement of two or more of the patient's surrogate markers. According to the present invention, surrogate markers for correlating the level of analgesia in a subject being administered an opioid, resulting in non-invasive method of predicting and monitoring the analgesic during treatment. Moreover, surrogate markers that correlate with blood concentration of opioid in the subject were identified. Accordingly the present invention provides a valuable clinical tool to evaluate and control pain treatment with opioids. Prediction method, a method suitable apparatus for carrying out the present invention, and apparatus used in the drug treatment of pain therapy, and the like are disclosed.FIELD 1