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METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING SHIGA TOXIN-PRODUCING ESCHERICHIA COLI INFECTION

机译:治疗和预防产志贺毒素的大肠埃希氏菌感染的方法和成分

摘要

PROBLEM TO BE SOLVED: To provide compositions and methods for eliciting an immune response in mammals against Shiga toxin-producing Escherichia coli (STEC), which is also called enterohemorrhagic Escherichia coli and verotoxin-producing Escherichia coli, such as O157 and O103, in particular, for treating and preventing STEC disease and STEC colonization of mammals.SOLUTION: There is provided a multiple-epitope fusion protein comprising more than one epitope of an immunogenic STEC protein derived from more than one STEC serotype, utilized for treating and preventing STEC disease and for reducing STEC colonization of ruminants and other mammals in order to reduce the incidence of health problems associated with STEC-contaminated meat and water.SELECTED DRAWING: None
机译:解决的问题:提供用于在哺乳动物中引发针对产生志贺毒素的大肠杆菌(STEC)的免疫应答的组合物和方法,该大肠杆菌也被称为肠出血性大肠杆菌和产生毒素的大肠杆菌,例如O157和O103,特别是解决方案:提供了一种多表位融合蛋白,其包含来自一种以上STEC血清型的免疫原性STEC蛋白的一个以上表位,用于治疗和预防STEC疾病和用于减少反刍动物和其他哺乳动物的STEC定植,以减少与STEC污染的肉和水有关的健康问题的发生率。

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