METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING SHIGA TOXIN-PRODUCING ESCHERICHIA COLI INFECTION

摘要

Compositions and methods for stimulating an immune response against Shigatoxin-producing Escherichia coli(STEC) antigens are disclosed. The compositions include a multiple epitopefusion protein comprising more than one epitope ofan immunogenic STEC protein from more than one STEC serotype. Additionalcompositions include at least two purified STECproteins, wherein the STEC proteins are selected from a full-length STECprotein, an immunogenic fragment or variant thereof,wherein at least one of the STEC proteins generates antibodies that react withSTEC 0157 and at least one other STEC serotype.