Maintaining bronchial patency by cytotoxicity, cytostatics, or local delivery of antineoplastic agents

摘要

A method for maintaining patency in a patient's bronchi is presented. A catheter is positioned within the bronchi. One or more target regions of the bronchial wall, submucosa, media and adventitia are located at or adjacent to the reduced bronchial carcinoma using a needle placed on the distal end of the catheter. And penetrated. Such penetration is accomplished by dilating a balloon placed on the distal end of the catheter. The balloon consists of at least two materials of different elastic modulus that allow the balloon's flexible but relatively non-inflatable deployment component and the balloon's elastomeric inflatable component. Through the injection needle, a predetermined amount of cytotoxic agent, cytostatic or anti-neoplastic agent is delivered to the target area. The amount delivered is effective to limit recurrent bronchial obstruction due to bronchial carcinoma recurrence by a therapeutically beneficial amount.