Molecular targets useful in the treatment of diseases associated with epithelial-mesenchymal transition and inhibitors of said targets

摘要

The present invention relates to methods and assays for identifying substances useful in the treatment of diseases associated with epithelial-mesenchymal transition (EMT), particularly fibrosis and cancer. The present invention provides polypeptide and nucleic acid targets, siRNA sequences based on these targets and antibodies to the targets. The invention further relates to a pharmaceutical composition comprising a target-based siRNA sequence and an antibody to the target for use in the treatment of diseases associated with epithelial-mesenchymal transition, particularly fibrosis and cancer. The present invention further provides an in vitro method for inhibiting epithelial-mesenchymal transition. [Selection figure] None